Saturday, February 19, 2011

Cefixime

Cefixime
Systematic (IUPAC) name
(6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxy
methoxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia-
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers
CAS number 79350-37-1
ATC code J01DD08
PubChem CID 5362065
DrugBank APRD00583
ChemSpider 4514923 YesY
UNII 97I1C92E55 YesY
KEGG D00258 YesY
ChEMBL CHEMBL1541 YesY
Chemical data
Formula C16H15N5O7S2 
Mol. mass 453.452 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 40% to 50%
Protein binding Approximately 60%
Half-life Variable
Average 3 to 4 hours
Excretion Renal and biliary
Therapeutic considerations
Pregnancy cat. B
Legal status  ?
Routes Oral
 YesY(what is this?)  (verify)
Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea,[1] tonsilitis,[2] and pharyngitis.[2]
The usual dose is 400 mg in two divided doses for up to 5-7 days.
It was sold under the trade name Suprax in the USA, until 2003 when it was taken off the market by drug manufacturer Wyeth after its patent expired. The oral suspension form of "Suprax" was re-launched by Lupin in the USA.

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